This page should help you solve typical problems, which can appear
while running .NET apps on this site.
Windows Updates
Ensure your Windows is up to date as this should install all dependencies for the apps.
.NET Framework
Install the required .NET Frameworks. Alternatively, use my One Click - Install All solution
Antivirus
As a last resort (something that shouldn't be necessary at all), try adding an exclusion for the application in your Antivirus.